Creatinine is a chemical waste molecule filter and disposed by the kidneys. Increasing blood level indicates problem surrounded by kidney functions.
So what happens when creatinine plane increases? Aside from an indication that it signals alteration in kidney functions,giant levels of creatinine at duplicate time can also break down the kidneys and liver and it can also cause an electrolyte inequality.
As its level rises, it manner the kidney function diminishes which will also have trouble near the rest of its vital functions. Surely, BUN will also rise, and everything will be contained by trouble. The sequence of the effects would then involve the entire body system which ultimately could become deadly and lead to departure in crust the kidney function is in flop.
Since we don't make inulin (NOT Insulin), creatinine stratum and creatinine clearance is a very convenient device of how well the kidneys are working or not carrying out their function. As the serum creatinine rises, this is an indicator that this molecule is not human being cleared by the kidneys at an optimal rate. Of course, we always evaluate the Cr surrounded by the context of hydration status, BUN, etc. But I hope that this very simplistic answer suffices.
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